Autologous cultured epidermis: industrialization of regenerative medicine.
نویسندگان
چکیده
要約:自家培養表皮「ジェイス」は,ヒト細胞を用い た日本初の再生医療製品であり,2007 年に承認された. 自家培養表皮は,患者自身の皮膚を原材料として作製 した表皮細胞シートである.ジェイスの製造は,3T3 J2 細胞のフィーダーと,ウシ胎児血清や増殖因子を添 加した培地を用いて表皮細胞を培養するGreen法を採 用しており,数 cm の皮膚から体表をすべて覆う面積 の表皮細胞シートを製造することができる.ジェイス を広範囲熱傷の熱傷創面に適用すると,表皮細胞が生 着することによって創が閉鎖される.ジェイスの生着 は,移植部位の状態に大きく影響されることがわかっ ている.生着を阻害する要因には,感染,炎症,物理 的刺激,細胞傷害性物質などが考えられる.ジェイス の有効性を発揮させるために,わが国の医療現場に適 した移植手技が標準化されることが望ましい.再生医 療製品では,細胞毒性が低い併用薬の選択が求められ ることから,薬理学的なサポートも重要である.
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عنوان ژورنال:
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica
دوره 137 3 شماره
صفحات -
تاریخ انتشار 2011